The type III secretion system (T3SS) is a sophisticated molecular apparatus that many Gram‐negative bacterial pathogens deploy to inject effector proteins directly into host cells. This machinery ...

Many pathogenic bacteria use special secretion systems to deliver toxic proteins into host cells. Researchers of Ludwig-Maximilians-Universitaet (LMU) in Munich have determined the structure of a ...

With antibiotic-resistant bacteria on the rise, scientists have been searching for ways to shut down the Type IV secretion system (T4SS), a protein complex on the outer envelope of bacterial cells ...

Six years ago, researchers described the first toxin ever found for the deadly pathogen Mycobacterium tuberculosis. However, the mechanism for its secretion from the bacterium was unknown. Now, ...

Bacteria have complex molecular machines that help them drive disease. Scientists can now leverage these machines to treat disease instead. It is nice to deliver drugs where you exactly want them, ...

Basic, acidic, basic again: for pathogenic bacteria such as Salmonella, the human digestive tract is a sea of change. So how do the bacteria manage to react to these changes? A team of researchers has ...

Six years ago, Michael Niederweis, Ph.D., described the first toxin ever found for the deadly pathogen Mycobacterium tuberculosis. This toxin, tuberculosis necrotizing toxin, or TNT, became the ...

Researchers at McMaster University have discovered a molecular “barcode” system used by disease-causing bacteria to distinguish between beneficial and toxic molecules. Published in the Proceedings of ...