Xenotransplantation models represent powerful tools for the investigation of healthy and malignant human hematopoiesis. However, current models do not fully mimic the components of the human bone ...

Researchers developed a humanized mouse model that better predicts how antibody drugs interact with the immune system. The ...

Please provide your email address to receive an email when new articles are posted on . The FDA approved the first chimeric antigen receptor therapy in 2017, authorizing tisagenlecleucel for treatment ...

Scientists at The Wistar Institute have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma. It has ...

In vivo models of human immunity in human tumor-bearing mice are frequently used to study mechanisms of targeted immunotherapies, safety, and efficacy. In a recent webinar Jenny Rowe, PhD, Scientist ...

Mice are commonly used as models of human disease, helping scientists to understand the workings of complex pathologies and develop safe and efficacious drugs. It is now possible to create a range of ...

A breakthrough for biomedical research promises new insight into immunotherapy development and disease modeling. Scientists at The University of Texas Health Science Center at San Antonio have created ...

Association of Preoperative Plasma Levels of Vascular Endothelial Growth Factor and Soluble Vascular Cell Adhesion Molecule-1 With Lymph Node Status and Biochemical Progression After Radical ...

A severe organ shortage plagues the progress of organ transplantation. One solution may be to generate human organs in other large mammals, however, that process is challenging. Now, researchers have ...